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This means they vary in how effective they are, the side effects they may cause and who they are suitable for.Broadly speaking, the options covered in this guide fall into two categories: Prescription GLP-1 medications, such as the Wegovy Pill (oral semaglutide) and Foundayo (orforglipron not yet approved in the UK), which help regulate appetite and increase feelings of fullness Over-the-counter fat absorption blockers, such as Alli (orlistat), which reduce the amount of fat your body absorbs from food In the UK, weight loss medications must be approved by the Medicines and Healthcare products Regulatory Agency (MHRA) before they can be prescribed