This finding suggests that GLP-1 drugs could play a crucial role in neurodegenerative disease prevention and treatment
Additionally, the cyclic trisulfide structure of LASSS, as opposed to the linear trisulfides such as GSSSG and cysteine trisulfide (Cys-SSS-Cys), could guarantee the unique reactivity of LASSS (see again Figure 1a for chemical structures)
Long-term studies are still needed to fully understand the risks and benefits of using GLP-1 drugs in addiction treatment
Rather than aiming solely at lysosomal disruption or cargo release, these approaches deliberately tune key lysosomal propertiesincluding luminal pH, enzymatic activity, membrane stability, and autophagic fluxto reprogram cancer cell survival and stress-adaptation pathways
However, equivalence estimates depend on the prespecified margin ( 2 percentage points) [35, 36], which, while clinically plausible, remains a subjective choice