The challenge is that GLP-1 and GIP are structurally similar but not identical
And it is far more common than most people realize
We found that internalized exendin-phe1-FITC was situated in the least, and exendin-asp3-FITC in the most, acidic endosomes (Supplementary Fig
doi: 10.1080/17425255.2023.2223959 [PubMed] 37552484 Dart RC, Mullins ME, Matoushek T, Ruha AM, Burns MM, Simone K, Beuhler MC, Heard KJ, Mazer-Amirshahi M, Stork CM, Varney SM, Funk AR, Cantrell LF, Cole JB, Banner W, Stolbach AI, Hendrickson RG, Lucyk SN, Sivilotti MLA, Su MK, Nelson LS, Rumack BH
(Alameda, CA, United States)