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Brazil's Ministry of Health is, however, running a two-year pilot study (Real-Bari) enrolling 250 SUS patients with severe obesity in Porto Alegre a necessary first step toward building the cost-effectiveness evidence that a Conitec recommendation would require

Its influence on hormones that govern hunger and energy use is well-documented in clinical studies

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Conditions that are often mistaken for ALS include multifocal motor neuropathy, cervical spine disorders, and inclusion body myositis (Kwan and Vullaganti, 2022)