Osteogenesis Imperfecta (OI) - Beagle Startseite are characterised by distinctive morphological

are characterised by distinctive morphological traits including a wide head

Affected dogs experience unpredictable seizures with increased aggression

The condition is progressive

that affect foetal development

giving an overall comma-like morphology to the body

Osteogenesis Imperfecta (OI) - Beagle Startseite are characterised by distinctive morphologicalOsteogenesis imperfecta is an autosomal dominant disease caused by a mutation in the COLA2 gene, which encodes collagen. Mutations altering the sequence can lead to disruptions of the collagen structure, which can lead to abnormally brittle bones that fracture very easily. The disease can be found in several dog breeds. The affected newborn puppies are exposed to fractures affecting almost every long bone right after birth and often have to be