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IUPHAR review: from foe to friend: Repurposing glucagon to treat obesity and type 2 diabetes
doi.org/10.1002/oby.70137
Pilichiewicz AN, Chaikomin R, Brennan IM et al (2007) Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men
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Unlike semaglutide which solely activates GLP-1R (one of the three pivotal receptors regulating glucose homeostasis), tirzepatide also activates glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) to enhance metabolic benefits with reduced side-effects 5
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