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B12 is water soluble, which means B12 doesnt build up in your system once youre at the appropriate amount for your body you will just eliminate any extra, so theres very little risk of an overdose
This dimeric interaction is vital to the outcome of Fc:FcRn binding, as asymmetrical removal of FcRn binding to one of the two sides of the Fc drastically reduces both cellular transport and the plasma half-life of IgG [56, 59, 60]
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