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Retrograde Mitochondrial-Nuclear Signaling One interesting feature of MOTS-c biology is that MOTS-c seems to travel to the nucleus of cells under conditions of stress and alter the expression of nuclear genes that control antioxidant defences as well as metabolic programs
It plays a key role in detoxification, fighting free radicals, and regulating melaninthe pigment responsible for skin color
Glutathione is also a constituent in the regulation of protein and gene expression, exchange reactions including thiol to disulfide ratios involve glutathione (4)
A higher level of oxidative stress was detected in patients with NASH compared to NAFLD and a reduction in the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and GGT, as markers of oxidative stress, was highlighted in NASH patients treated with GSH, with a consequent reduction of alanine transaminase (ALT)
Immediate discontinuation and treatment may be required if these reactions occur
