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It is characterized by abnormal hematologic findings
The disease is neither progressive nor life-threatening
Mutation: DSG1 gene
Mutation: LARGE1 gene
Zentronukleäre Myopathie (IMGD) - Deutsche Dogge Mischling CatCheck oder DogCheckCharacteristic signs of centronuclear myopathies include generalized muscle weakness, atrophy, predominance of type I fibres, and aberrant cell positioning of nuclei and mitochondria. In Great Danes generalized muscle atrophy, exercise intolerance, exercise induced tremor and muscle wasting characterize the disease. The disease typically starts before 10 months of age, is highly progressive, and most of the affected dogs are euthanized before 18
