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People with diabetes, heart disease, digestive and kidney diseases, or a family history of medullary thyroid cancer need extra evaluation before using these medications
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Written by: Rafael Guimares, MS & Kristen DiFilippo, PhD, RDN Glucagon-like peptide 1 receptor agonists, commonly known as GLP-1 medications, are increasingly used in the treatment of type 2 diabetes and obesity (Drucker 2018
On the one hand, by triggering the Gq/PLC signaling pathway and mitochondrial reverse electron transport-mediated ROS bursts, it induces the oligomerization and activation of the NLRP3 inflammasome, driving the maturation and secretion of pro-inflammatory cytokines such as IL-1 and IL-18, thereby significantly amplifying local intestinal inflammatory responses (Bauset et al., 2022) (Figure 1B)
SURMOUNT-OSA (reduction in apnoeahypopnea in obstructive sleep apnoea) Survodutide : MASH trial (resolution of MASH, improvement in fibrosis) Another key event in 2024 was the readout of the first head-to-head trial in obesity, Lillys SURMOUNT-5, pitting tirzepatide against semaglutide, with the former demonstrating superior weight loss
