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They should be used in conjunction with a nutrient dense diet and a focus on gaining physical fitness and building or maintaining muscle mass

Participants initiated treatment at lower doses before advancing through predetermined increments

Creatine supplementation can increase serum creatinine levels independently of true kidney function, potentially affecting eGFR readings

Chromatographic Adjustment: Switched from ammonium bicarbonate to 1% formic acid mobile phase to eliminate matrix suppression and bring results within acceptable %RE limits

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