Kupfertoxikose (CT) - Labrador Retriever option-set-443684-checkbox-1 In dogs with more extensive

In dogs with more extensive CEA disease the hypoplasia of retina or coloboma development may occur

and make well-informed decisions – based on solid genetic evidence

Lesions persist for weeks to months

caused by mutations in FVIII gene

congenital developmental syndrome and progressive single organ dysfunction

Kupfertoxikose (CT) - Labrador Retriever option-set-443684-checkbox-1 In dogs with more extensiveCopper metabolism disorders are genetic disorders of copper metabolism in the liver caused by mutations in two genes that code copper transporters ATP7A and ATP7B. The ATP7A transporter is crucial for copper transport from fibroblasts into the liver and the ATP7B is crucial for copper export from the liver. Mutations in the ATP7A result in defective ATP7A transporter so the copper cannot be properly exported from fibroblasts and imported into the