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In surgery, the torn tendon is reattached to the kneecap or reinforced with tissue to restore function

The table below shows how one 5 mg vial behaves at different diluent volumes for a fixed 250 mcg (0.25 mg) dose: Larger draw volumes are easier to measure precisely, which is why many people favor more diluent the trade-off is that a heavily diluted vial holds a larger total liquid volume that must be stored and used within the solution's stability window

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Further research should assess a larger cohort size to confirm that A-T disease progression is attenuated upon NR supplementation

The manufacturer (EMD Serono) voluntarily discontinued Geref in 2008 for commercial reasons, not due to safety concerns