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Different types of polyphenols may have different mechanisms in preventing cisplatin ototoxicity, and may act synergistically in enhancing its anticancer activity to reduce side effects.EGCG has antioxidant, anti-inflammatory, and inhibitory effects on Caspase-1 and NF-B, and curcumin regulates the Bcl-2/BAX ratio, inhibits the mitochondrial apoptotic pathway, and reduces Caspase-3 activation
also identified that FSP1 can prevent ferroptosis through synthetic lethal CRISPRCas9 screening [47, 48]
Btn bunlar anabolik sreler iin nemli olabilir, nk ok yksek miktarda ATP ve protein sentezinin uyarlmas, ya asitlerinin verimli yanmasyla salanr
An antitumor Bis(N-Heterocyclic Carbene)Platinum(II) complex that engages asparagine synthetase as an anticancer target
[Article] [PubMed]99
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