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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations 8-OH-dg: 8-hydroxy-2-deoxyguanosine AM: airway macrophage BAL: bronchoalveolar lavage ELF: epithelial lining fluid GSH: glutathione (reduced form) GSSG: glutathione disulfide (oxidized form) HAT: histone acetyltransferase HDAC: histone deacetylase ICS: inhaled corticosteroid MDA: malondialdehyde PARP: poly (ADP-ribose) polymerase References Fitzpatrick AM, Gaston BM, Erzurum SC, Teague WG 2006 Features of severe asthma in school-age children: atopy and increased exhaled nitric oxide

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For tesamorelin, the visceral-fat trials also reported improvements in lipid parameters lower triglycerides and an improved total-to-HDL cholesterol ratio alongside the VAT reduction