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When acetaldehyde builds up faster than your liver can convert it, you'll feel those classic hangover symptomsheadaches, nausea, sensitivity to light and sound, and the vague sense that gravity has become extra vengeful

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[23] On the other hand, certain drugs like isoniazid, hydralazine, and some penicillamine can cause vitamin B deficiency and might necessitate concurrent pyridoxine supplementation

PMID 14144484

The mitochondria become sluggish, fragmented, and unable to meet the daily energy demands of the body, resulting in the debilitating, leaden fatigue that characterizes these conditions