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Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH: Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose
This small but mighty tripeptide (made from glutamine, cysteine, and glycine ) sits inside nearly every cell, where it plays multiple roles in maintaining cellular youth and function
Based on affinity chemical proteomics, the chloroacetamide part of the RSL3 structure is essential for its activity
Subsequent assays preincubating AX in the presence of the thiol-containing compounds ( Figures 5 and 6 ) clearly showed their ability to decrease AX availability or potency
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