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10.1038/s41591-024-03169-2 19 ChenY.-R.ZweierJ

If you have heart or kidney disease or are on fluid restriction, follow your healthcare professional's specific guidance about fluid intake

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Common physiological factors include: increased hunger hormone signaling reduced satiety cues metabolic adaptation after weight loss changes in energy balance return of previous eating patterns The body naturally adapts to weight changes

For individuals with metabolic risk factors, insulin resistance, chronic inflammation, or a family history of obesity-associated cancers, GLP-1 therapy in the context of a comprehensive, physician-guided longevity programme may represent a valuable adjunct to conventional preventive medicine strategies