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Bariatric surgery-mediated weight loss is associated with both reduced cancer risk and mortality 11 , with improved therapeutic effectiveness, although the mechanisms remain unclear
However, the continuation into phase 3 reflects strong preliminary evidence from earlier studies and growing clinical interest in its metabolic effects
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"We think that some of these people may be changing behavior, nutrition, lifestyle, [and] also may be changing the hormones in their body by being on [GLP-1 medications], changing how their brain sort of operates or functions permanently," Narula said
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