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Similarly, ketone bodies (e.g., -hydroxybutyrate) produced by the liver under microbial regulation serve not only as energy substrates but also remodel the epigenetic landscape of pro-angiogenic genes by increasing H3K9bhb levels and chromatin accessibility, and upregulating Carnitine Palmitoyltransferase 1A (CPT1A) and associated genes, thereby conferring cardioprotection 108

Rotating injection sites and following proper injection techniques can reduce discomfort

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