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Cold medication causes vasoconstriction, making vessels tighter and more prone to rupture

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Dehydration and volume depletion, for example, due to vomiting and diarrhea, can increase this risk

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[41] [42] The hypothesis that melatonin synthesis occurs within mitochondria and chloroplasts suggests an evolutionary and functional significance of melatonin in cellular energy metabolism and defense mechanisms against oxidative stress, reflecting the molecule's ancient origins and its multifaceted roles across different domains of life

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