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The gradual dose titration recommended in product SmPCs helps minimise gastrointestinal intolerance

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At the same time, the muscles around the joint begin to weaken, which takes away crucial support for stabilizing and projecting the joint

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More important than my observation is the following: In comments by Thompson and Sturmer published in the journal Diabetes Care in 2023, about a study of GLP-1s and the risk of thyroid cancer conducted by Bezin et al which was published in the same journal issue, Thompson and Sturmer conclude that Thyroid cancer is a rare outcome, however, and the potential increase in absolute risk is very small