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Moreover, metformin has been demonstrated to independently regulate menstrual cycles and ovulation, which further enhances fertility ( 2 Mechanisms of metformin alleviating anovulatory infertility in polycystic ovary syndrome For females of childbearing age, the most significant consequence of PCOS is infertility, for which the pathogenesis is still unclear

According to the SmPC and NICE guidance (TA875), Wegovy must be used as an adjunct to a reduced-calorie diet and increased physical activity for optimal results

10.1001/jama.2021.1831 77 WangQ