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Drugs R D 2012;12(1):29-34

Pleiotropic Benefits of the Angiotensin Receptor Blocker Candesartan in a Mouse Model of Alzheimer Disease

This is where glutathione steps in to protect the cell

That's the mechanism behind the "tan," and it's also exactly why the peptide's effects are so unpredictable: you're overriding a hormonal signal, not applying a topical product