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Biomaterials 116, 19

While NAC does not treat progesterone hypersensitivity itself, it may help reduce inflammatory burden and oxidative stress associated with immune activation in autoimmune progesterone dermatitis (APD)

Look for practitioners who are certified in functional medicine (IFMCP), environmental medicine, or who have specific training in the Shoemaker Protocol

Dosage and administration Typical protocols in the literature and clinical practice use subcutaneous injection , often run in a loading-then-maintenance pattern: a higher loading dose over the first 46 weeks, then a lower maintenance dose

This approach ensures that patients with genuine deficiency receive rapid, effective treatment while those without deficiency are not subjected to unnecessary procedures