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in anti-aging medicine, with positive effects on quality of life and the prevention of chronic diseases.91 IM8 uses dihydroberberine, a more bioavailable form that has been shown to be effective at 100mg doses.92 Astaxanthin (6mg): Like the other ingredients in Daily Ultimate Essentials, astaxanthin supplementation is linked to improvements in cardiovascular health,94 mitochondrial function,95 and oxidative stress.96 Effective doses start at 6mg.94 96 Spermidine (3mg): Much of what we said about astaxanthin goes for spermidine as well.97 98 Clinical doses start at around 3mg.99 Except for the PQQ, all of the ingredients fall within a clinically effective range, albeit sometimes toward the low end of that range