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Under the AffaMed Letter, we granted AffaMed a right of first negotiation, or the Option, to enter into a license agreement to exclusively develop, register and commercialize GB-102 solely in the territories of China, Hong Kong, Taiwan, Macau and South Korea

50 In vitro experiments suggest that SEMA may participate in regulating the fibrosis process by improving factors such as inflammatory or metabolic triggers of fibrosis, like IL-6 and free fatty acids, as well as fibrotic structural features

GLP-1 RA SmPCs (e.g., semaglutide) generally report no clinically relevant effect on overall drug exposure for most oral medicines, but individual monitoring remains prudent for narrow therapeutic index agents

Use in Local Nasal Conditions: Utilizing nasal spray TB-500 while experiencing a local nasal condition may jeopardize systemic absorption

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