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Many of the effects of insulin and glucose are mediated through adipocytes and adipose tissue, and the vitamin D receptor is abundantly expressed in adipocytes and is involved in their regulation (Clemente-Postigo 2015
Toll-like receptors (TLRs) play a key role in microorganism and viral particle recognition and activation of the innate immune system (Sasai and Yamamoto, 2013
The problem with natural amylin is that it aggregates rapidly and has a very short half-life, making it impractical for therapeutic use
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Interestingly, recent studies have proposed that DNA methylation can lead to the exclusion of a histone variant (H2A.Z), preferentially located at active gene promoter 36,37
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