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Elevated levels of IGF-1 have been associated with an increased risk of certain cancers, such as breast, prostate cancer, and colorectal cancers, in some studies

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In integrated transcriptomic and single-nucleus RNA sequencing (snRNA-seq) analyses, necroptosis was identified as a highly enriched RCD pattern in DKD tubules, defining distinct patient subtypes that correlate closely with chronic inflammatory responses and macrophage infiltration (229)

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