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Studies has demonstrated that increasing the Nrf2 levels in astrocytes inhibits apoptosis 46 and that Nrf2 translocates into the nucleus to regulate gene expression, crucial for oxidative stress and cardiac apoptosis induced by hypoxia/reperfusion (H/R) 47,48,49

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GIP also appears to have direct effects on adipose tissue, potentially improving the way fat cells respond to metabolic signals