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Synthroid and Acetaminophen Interaction: What You Need to Know At a glance Drug pair / levothyroxine (Synthroid) + acetaminophen (Tylenol) Interaction severity / minor in healthy adults per Lexicomp and Clinical Pharmacology databases Pharmacokinetic overlap / both undergo hepatic glucuronidation via UGT enzymes CYP involvement / acetaminophen is oxidized by CYP2E1 and CYP1A2