Each one of these agents will need to be carefully scrutinised to ensure they preserve or exceed the benefits and safety profile of GLP-1RA alone, without introduction of unanticipated new liabilities impacting therapeutic safety
Mild side effects, such as soreness at the injection site, are rare
Its been used for centuries in traditional systems like Chinese and Ayurvedic medicine to treat a wide range of conditions from digestive issues to infections and metabolic disorders
Second, as mentioned above, c-Met inhibitors which target the interaction between HGF and c-Met may lose efficacy owing to cell attachment (Wang et al., 2001), gene amplification of c-Met, DCP binding to c-Met (Suzuki et al., 2005), gene mutation in the c-Met activation loop (Okuma and Kondo, 2016) and crosstalk with other membrane receptors (Garcia-Vilas and Medina, 2018)
This can help reduce appetite and make it easier to eat less