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Clinical trial objectives The purpose of the clinical study in humans was to evaluate the efficacy of four weeks supplementation of a combination of vitamin B6, B9, B12, and taurine on motivated behavior, as a primary outcome, and on attentional performance, and self-reported mood (e.g., fatigue, vigor) as secondary outcomes

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Interventional studies Seven interventional studies (Table 2) were included in the systematic review all of them were randomized controlled trials with a cross-over study design [1319]