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It would also help explain a clinical observation discussed later: the gastrointestinal side effects associated with amylin analogs (nausea, early fullness) tend to be most pronounced during dose escalation and to ease with continued treatment, a pattern consistent with partial adaptation of the very gastric mechanism in question

Concurrently, DON impaired transmembrane transport and lipid homeostasis by suppressing genes such as ATP-binding cassette subfamily A member 4 (ABCA4) 73 , whereas GA induced transporters for detoxification and lipid efflux (e.g., ABCB11 74 and ABCA1 75 )

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Food and Drug Administration-approved (FDA-approved) for the treatment of type 2 diabetes and has an additional indication for reducing the risk of major cardiovascular events, such as heart attack or stroke in individuals with type 2 diabetes and cardiovascular disease

For context on the GLP-1 medications themselves: in the head-to-head SURMOUNT-5 trial, tirzepatide produced a 20.2% average body weight reduction vs