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Animal models can point research in a direction, but many compounds that shine in rats never reproduce those effects in controlled human trials

Strong family history of hormone-sensitive cancers or genetic predisposition (BRCA1/2, Lynch syndrome): Elevated IGF-1 carries meaningful epidemiological risk that outweighs potential benefit without oncology clearance

As always, talk with a healthcare practitioner about what fits your routine

Over-the-counter options like gentle moisturizers and barrier repair creams can also make a meaningful difference

Wegovy is a weight loss injection that is taken once a week, containing semaglutide