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With respect to analgesia, GSHee did not elicit observable changes in analgesia status of freely moving rats per se whereas the duration of fentanyl analgesia was increased in rats pretreated with the thiolester
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Given that CoQH2 serves as an alternative anti-ferroptosis system operating in parallel with GPX4, the differential metabolic environments between malignant and normal cells likely contribute to the divergent effects of lactate on ferroptosis sensitivity observed across these cellular contexts
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