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Despite this conceptual shift, peptide mediators of bonemusclefat crosstalk remain among the most underexplored endocrine systems, in part because their biology challenges traditional organ-based models of metabolism

In addition, PVH GLP-1R knockout in juvenile mice led to increased adult body weight and food intake with no changes in energy expenditure, suggesting potential compensatory adaptation during development [94]

doi:10.1007/s00429-014-0714-z 117

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