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Cocaine and amphetamines (stimulants) All animal studies retrieved for stimulants misuse involved exendin-4 among GLP-1RAs and highlighted a reduction of cocaine and amphetamines intake and end effects (for example, increased locomotor activity) via modulation of dopaminergic transmission in areas including the nucleus accumbens and the ventral tegmental area 91,92,93,94,96,97,98,99,100,101,102,103,105 , as well as modulation of inflammatory mechanisms 104
In addition, studies have shown that use of GLP-1RA has significant reduction in MI, CV mortality, and/or MACE in patients with a history of MI [12, 76], with our data demonstrating reduction in unstable angina and coronary revascularization risk in the secondary preventative cohort
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