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Regarding thyroid effects: rodent studies with related GLP-1 receptor agonists have shown C-cell changes, but no causal link to thyroid tumours in humans has been established in UK or EU regulatory assessments
The combined activation creates a synergistic effect on weight reduction, glycemic control, and liver fat metabolism
The 5-7 day mark is when most patients see significant improvement
Studies in women with PCOS show that GLP-1 therapy produces weight losses of 510% over 612 months, with concurrent improvements in menstrual regularity, fertility markers, and cardiovascular risk factors
However, some users report experiencing yeast infections while on semaglutide, especially if they have predisposing factors such as diabetes or high blood sugar
