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The serious adverse event rate reported in the high dose methylprednisolone group was 10.9% compared to 2.8% in the placebo group
Tirzepatide doses range from 2.5 mg to 15 mg
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These data reinforce the potential clinical benefits of long-term therapy for people living with obesity and pre-diabetes. SURMOUNT-1 (NCT04184622) was a multi-center, randomized, double-blind, parallel, placebo-controlled trial comparing 5 mg, 10 mg, and 15 mg of tirzepatide to placebo as an adjunct to a reduced-calorie diet and increased physical activity in adults with pre-diabetes and obesity or overweight with at least 1 of the following comorbidities: hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease
This means researchers can use these compounds only for in-vitro laboratory testing and controlled experimentation
