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In contrast, Exos derived from cancer cells, such as HCC and colorectal cancer play an essential role in affecting the tumor immunosuppressive microenvironment by mediating ferroptosis in immune cells [219, 220]

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That last list is the "503A bulks list." Appearing on it is a compounding-eligibility decision it is not FDA approval of a finished drug, which is an entirely separate pathway

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Most plateaus resolve with the simpler intervention