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Treating cells with cumene hydroperoxide was shown to enhance eryptosis, whereas the antioxidant NAC mitigated this process by enhancing RBC deformability and reducing levels of ROS, calcium, and PS exposure, and demonstrated that oxidative stress plays a crucial role in eryptosis, with pro-oxidants promoting and antioxidants limiting eryptotic processes [413]

Malabsorption can cause severe B12 deficiency

Free radicals can react with normal cellular structures which in turn can cause damage and cell death