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Laser and other light-based therapies are being evaluated as potential therapies in refractory cases, although they carry the risk of worsening the condition in some cases.[] Recently, several systemic agents have been introduced for the treatment of melasma, most often as adjuncts to the established therapeutic modalities
Furthermore, because some NAPQI is created regardless of the function of the other 2 pathways, failure in the glutathione-dependent pathway is expected to result in the accumulation of NAPQI and subsequent toxicity, even if the other 2 pathways are functional.It is not surprising that both sulfation- and glutathione-dependent pathways are aberrant in the same population because they are metabolically connected [41,72,73]
Important components include superoxide dismutase, catalase, glutathione peroxidase, dietary antioxidants, and glutathione itself
Proposed mechanisms of TB-500: TB-500 is primarily discussed for its role in cell migration and cytoskeletal remodeling