The semaglutide side effects users reported most often in clinical trials were: Nausea Diarrhea Vomiting Constipation Abdominal pain Headache Fatigue More than 20% of trial participants reported these side effects, with 44% reporting nausea and 30% reporting diarrhea compared to 24% or fewer for vomiting, constipation, and abdominal pain
Elmendorf AJ, Yousefian M, Kim IM, Hardaway JA, Habegger K, Flak JN
Melasma, in the form of tan or brown patches, may develop on the forehead, cheeks, temples and upper lip
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In addition to the above, DSIP has demonstrated some potential as a therapy for other health concerns, at least in animal studies