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While evidence supports holding semaglutide at least three weeks pre-op, reinitiation should wait until the patient tolerates a regular diet without nausea or vomiting

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When used alone, semaglutide has a low risk of hypoglycemia

Symptoms of high cortisol (Cushing's syndrome) may include: Unexplained weight gain, particularly around the abdomen and face Purple striae (stretch marks) on the skin Easy bruising and thinning skin Muscle weakness High blood pressure and elevated blood glucose Mood changes, including anxiety and depression Symptoms of low cortisol (adrenal insufficiency) may include persistent fatigue, weight loss, low blood pressure, dizziness, and hypoglycaemia

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