Research endpoints include droplet or particle-size distribution, mucosal retention, excipient compatibility, peptide integrity, and formulation stability
The membrane was blocked with 3% non-fat milk (BioRad, Hercules, CA, United States) at room temperature for 1.5 h, washed, and incubated with primary antibodies (Supplementary Table 3) at 4C overnight on a rotating shaker
From the phase 3 trials at the 9 mg and 12 mg doses: Nausea: 38.1% (9 mg) to 43.2% (12 mg) versus 10.7% with placebo Diarrhea: 34.7% (9 mg) to 33.1% (12 mg) versus 13.4% with placebo Constipation: 21.8% (9 mg) to 25.0% (12 mg) versus 8.7% with placebo Vomiting: 20.4% (9 mg) to 20.9% (12 mg) Compare those numbers to Mounjaro and the difference is clear
The nasal route theoretically offers direct nose-to-brain transport via the olfactory nerve pathway, bypassing the blood-brain barrier
[3] Davis TP, Abbruscato TJ, Egleton RD