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While GLP-1 receptor agonists and Metformin are generally considered safe, each comes with specific rare side effects worth noting

In late August 2015, the US FDA issued a warning that drugs like sitagliptin, saxagliptin, linagliptin, alogliptin, and other DPP-4 inhibitors could cause joint pain that can be severe and disabling

In patients with normal kidney function, it was strongly and significantly associated with the risk of venous thromboembolism (Brodin 2012)

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