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The safety profile observed across the ACHIEVE studies was consistent with previous investigations of GLP-1 receptor agonists. Gastrointestinal adverse events, including nausea, diarrhea, vomiting, dyspepsia, and decreased appetite, were the most commonly reported side effects. Treatment discontinuations due to adverse events increased with higher doses of Foundayo but remained generally consistent with expectations for the GLP-1 class. No new safety signals were reported. Based on findings from ACHIEVE-1 through ACHIEVE-5, Lilly announced plans to submit Foundayo to the US Food and Drug Administration for the treatment of type 2 diabetes by the end of the second quarter. References Lilly's oral GLP-1 Foundayo (orforglipron) delivered superior A1C control and weight loss in three pivotal type 2 diabetes trials

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Graphical Abstract Similar content being viewed by others Oncometabolites and their impact on the epigenetic landscapes of prostate cancer Overview of prostate cancer The prostate is the largest accessory gland in the male reproductive system, consisting of tubulo-alveolar glands

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