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Immune interventions It is becoming increasingly clear that autoreactivity to islet antigens is also present in healthy individuals [59] and autoimmunity recurs after autologous nonmyeloablative haematopoietic stem cell transplantation [105, 106]

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Therefore, the inhibition of xCT-mediated cystine transport, cystine depletion, limited cysteine biosynthesis, impaired GSH synthesis, or inactivation of GPX4 can induce ferroptosis [49]