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In the motor system, glutamate is involved in the coordination of movement, with excitatory projections from the motor cortex to the spinal cord facilitating motor control

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In animal models of neurodegenerative disease, activation of TGR5 receptor was neuroprotective, decreasing neuronal death and inflammatory response (Monteiro-Cardoso et al., 2021)

Vaish S et al

Theres clear evidence that dietary patterns and specific nutrients are vital to the mitigation of inflammation, oxidative stress/mitochondrial dysfunction, and gut dysbiosis.3 Nutrients also are necessary to support methylation, neurobiological networks, and hormone signaling pathways that modulate mood, appetite, sleep, neurogenesis, and cognitive function.16 Several metabolic actors including insulin, GABA (gamma-Aminobutyric acid), brain-derived neurotrophic factor (BDNF), and other gut hormones play roles in stress-related and affective disorders.17 Metabolic syndrome, characterized by higher levels of glucose, total and LDL cholesterol, BMI, abdominal obesity, and low HDL cholesterol, has been associated with a higher prevalence of depression compared with those without the condition